Prevention of Oral Malodor With an Oral Sticker Containing Herbal Formula

Status Completed

Clinical Trial Summary

the use of a herbal formulation containing sage, echinacea,lavender and mastic gum would prevent oral malodor if delivered in an appropriate delivery system to enable slow release of the active ingredients.

Clinical Trial Description

Oral malodor (Halitosis, Fetor ex ora) is a common and disturbing condition, affecting according to some studies about one quarter of the population. This condition may start at any time from early childhood through adolescence, adulthood and old age and vary in character and severity.The bacteria responsible for malodor production are for the most part Gram negative oral bacteria (2- 4) such as Porphyromonas gingivalis, Fusobacterium nucleatum and Prevotella intermedia. These bacteria reside on various locations within the oral cavity (e.g. tongue dorsum, interdental space, periodontal pockets, tonsils) and breakdown salivary and oral proteins into their amino acid building blocks. Some of these amino acids (e.g. methionine, cysteine, tryptophan, lysine) are further metabolized yielding malodorous volatile products such as methylmercaptan, hydrogen sulfide, indole, skatole and cadaverine (5-7). These are foul smelling compounds, which are released during exhalation and speech.in our study we intend to use an aprooved mucosal sticker containing carbopol and hydroxypropylcellulose mixed with the herbal ingredients and placed on the palatal mucosa.than mesure the volatile sulfur compounds to observe if the composition has antimalodor effect and for how long. the herbal ingredients are used for many years for medicinal and nutritional purposes. if our hypothesis is right we might have another formulation and method of application to prevent oral malodor ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00250289
Study type	Interventional
Source	Hadassah Medical Organization
Contact
Status	Completed
Phase	Phase 1
Start date	March 2006
Completion date	September 2008

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04279106` - Effect of Single Rinsing With Three Different Types of Mouthwash on VSC Levels in Morning Breath	N/A
Completed	`NCT04914208` - Effect of Wearing Face Masks on Salivary Parameters and Halitosis	N/A
Completed	`NCT05413382` - Effect of an Investigational Lozenge (Biofresh® 4plus) Versus Placebo Control on Oral Malodor (Intra-Oral Halitosis)	N/A
Completed	`NCT05524948` - A Clinical Study to Examine the Effects of an Experimental Toothpaste Compared to a Regular Fluoride Toothpaste on Breath Odor in a Population With Gingivitis	N/A
Completed	`NCT02113137` - Oral Hygiene Procedures on Reduction of Oral Malodor	Phase 4
Completed	`NCT02689297` - Three Different Oral Hygiene Regimes on Three Volatile Sulfur Compounds	Phase 4
Completed	`NCT01046812` - Halitosis Devised Questionnaire Evaluating a New Treatment	N/A
Withdrawn	`NCT02665780` - Assessing the Effect of Periodontal Debridement, Tongue Cleaning and Mouth Rinsing for the Treatment of Oral Malodour	N/A
Completed	`NCT01948349` - Impact of Bracket Design and Oral Hygiene Maintenance on Halitosis in the Orthodontic Patient	N/A
Recruiting	`NCT02007993` - Photodynamic Therapy in Adolescents Halitosis	N/A
Completed	`NCT01269957` - Halitosis and Mouth Breathing in Children	N/A
Completed	`NCT04632004` - Questionnaire Regarding the Effect of Wearing Face Masks on Oral Health	N/A
Completed	`NCT04998617` - Effects of Curcumin-containing Toothpaste on Dental Biofilm and Associated Oral Halitosis	N/A
Completed	`NCT01139073` - A New Portable Monitor for Measuring Odorous Compounds in Oral, Exhaled and Nasal Air	N/A
Not yet recruiting	`NCT00875927` - Effects of Breezy Candy on Halitosis	Phase 1/Phase 2
Completed	`NCT03196648` - Randomized Trial of a Gum Health Formulation	N/A
Recruiting	`NCT03346460` - Effect of Photodymamic Therapy With Urucum and LED in the Reduction of Halitosis	Phase 2
Completed	`NCT03468595` - Clinical Evaluation of Some Local Antimicrobial Agents' Adjunctive Effects On Periodontal Parameters and Halitosis	N/A
Completed	`NCT02794766` - Inulin and S. Salivarius Reduce Halitosis	Phase 2
Completed	`NCT02628938` - Effect of Miswak and Miswak Extract on Oral Malodor	Phase 2