SASH: Sodium Accumulation Study In Haemodialysis — SASH  

End Stage Renal Disease on Dialysis Clinical Trial

Official title: Sodium Accumulation Study In Haemodialysis

Status Not yet recruiting

Clinical Trial Summary

Haemodialysis (HD) sustains life in patients with end-stage kidney disease (ESKD) but is associated with a marked increase in incidence of cardiovascular disease (CVD) and high annual mortality rates. The pathogenesis of CVD in patients on HD is multifactorial and complex but hypertension is thought to be a major contributing factor. Sodium balance is normally regulated by the kidneys in health but has to be achieved by sodium removal during HD for those with ESKD. Recent evidence suggests that accumulation of sodium in the skin and / or muscle may be a critical factor impacting the development of hypertension and CVD in patients with ESKD and non-invasive methods are therefore required to study tissue sodium accumulation in this context. This study aims to determine the change in skin and muscle sodium content in patients undergoing haemodialysis. Participants will have a single haemodialysis session, and undergo two MRI scans (one prior to and one following dialysis).

Clinical Trial Description

It has been proposed that tissue sodium accumulation in skin and/or muscle is a key factor in hypertension. 23Na MRI allows the assessment of skin and muscle sodium storage and will therefore be a valuable tool in elucidating the role of tissue sodium accumulation in the pathogenesis of salt-sensitive hypertension and cardiovascular morbidity and mortality. Moreover, if haemodialysis in patients with end-stage kidney disease (ESKD) results in changes in tissue sodium, the development of 23Na skin and muscle measures would allow for a method to correlate skin tissue sodium content with detailed cardiovascular and functional assessments.

Participants will have a single haemodialysis session, and undergo two MRI scans (one prior to and one following dialysis), in conjunction with clinical data collection (eg. blood samples, bioimpedance analysis, skin autoflorescence). ;

Related Conditions & MeSH terms

• End Stage Renal Disease on Dialysis
• Haemodialysis
• Kidney Failure, Chronic

• NCT number: NCT05128188
• Study type: Observational
• Source: University Hospitals of Derby and Burton NHS Foundation Trust
• Contact: Rebecca Noble, Dr
• Phone: 01332340131
• Email: mszran@exmail.nottingham.ac.uk
• Status: Not yet recruiting
• Start date: January 15, 2022
• Completion date: June 15, 2022