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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT04547608
Other study ID # WonkwangUH7
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date May 1, 2020
Est. completion date September 4, 2020

Study information

Verified date September 2020
Source Wonkwang University Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Temporal summation of pain, which is defined as the perception of increasingly greater pain evoked by repetitive painful stimuli, is highly variable between individuals. This study aimed to determine the impact of the timing of rocuronium after induction with propofol on temporal summation of pain in gynecologic laparoscopic surgery.

Recruitment information / eligibility

Status Completed
Enrollment 100
Est. completion date September 4, 2020
Est. primary completion date May 30, 2020
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Female
Age group 19 Years to 60 Years
Eligibility Inclusion Criteria:

- Elective gynecologic laparoscopic surgery

- American Society of Anesthesiologists' physical status class) I-II

Exclusion Criteria:

- Menopause (to exclude the hormonal effect on pain)

- Patients who had muscular, cardiovascular, hepatic or kidney disorders and patients with a history of medication who would affect muscle relaxants were excluded from this study.

- Patients with difficult venous access on forearm, a known allergy to propofol or rocuronium, chronic pain, pregnancy, and those who had received analgesics or sedatives within the previous 24 hours, were excluded from the study.

Study Design

Related Conditions & MeSH terms


The difference of the timing of rocuronium administration after propofol injection
The difference of the timing was rocuronium was administered immediately after propofol injection or when BIS score became below 60 after propofol administration.


Country Name City State
Korea, Republic of WonwangUH Iksan Jeonbuk

Sponsors (1)

Lead Sponsor Collaborator
Wonkwang University Hospital

Country where clinical trial is conducted

Korea, Republic of, 

References & Publications (4)

Ayoglu H, Altunkaya H, Ozer Y, Yapakçi O, Cukdar G, Ozkoçak I. Does dexmedetomidine reduce the injection pain due to propofol and rocuronium? Eur J Anaesthesiol. 2007 Jun;24(6):541-5. Epub 2007 Jan 23. — View Citation

Cheng JC, Erpelding N, Kucyi A, DeSouza DD, Davis KD. Individual Differences in Temporal Summation of Pain Reflect Pronociceptive and Antinociceptive Brain Structure and Function. J Neurosci. 2015 Jul 1;35(26):9689-700. doi: 10.1523/JNEUROSCI.5039-14.2015. — View Citation

Hwang SM, Cho SH, Lim SY, et al. The efficacy of BIS monitoring for the preventing of withdrawal movement on the intravenous injection of rocuronium. Korean J Anesthesiol 2005;49:293-7.

Lim BG, Lee IO, Kim YS, Won YJ, Kim H, Kong MH. The utility of bispectral index monitoring for prevention of rocuronium-induced withdrawal movement in children: A randomized controlled trial. Medicine (Baltimore). 2017 Jan;96(2):e5871. doi: 10.1097/MD.0000000000005871. — View Citation


Type Measure Description Time frame Safety issue
Primary the grade of rocuronium induced withdrawal movement. withdrawal movements were graded by the investigator according to the following scale:
- no pain (no response);
- mild pain (movement at wrist only);
- moderate pain (movement involving the arm only with elbow or shoulder);
- severe pain (generalized response or movement in more than one extremity
during anesthesia induction
Secondary visual analog scale (VAS) for injection pain check VAS for pain after propofol administration. visual analog scale with 100 mm for pain after surgery. 0 = no pain, 100 = the worst pain during anesthesia induction
Secondary VAS for pain check VAS with 100 mm for pain after surgery. 0 = no pain, 100 = the worst pain at 1 hour, 24 hours and 48 hours
Secondary Patient controlled analgesia (PCA) Opioid consumption check the volume of PCA Opioid consumption (ml) (PCA) pump containing fentanyl (800 ug), ketorolac (150 mg), and ramosetron (0.6 mg) in a total volume of 150 mL of saline was set to deliver a basal infusion of 2 mL/h and bolus doses of 0.5 mL, with a 15-min lockout period for postoperative analgesia. at 24 and 48 hours
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