Digestive Cancer Clinical Trial
Official title:
LIPIDOXA, a Pilot Study of Analysis of Chronic Neuropathic Pain Markers in Patients Treated With Oxaliplatin-based Regimen
The role of oxidative stress in the development of oxaliplatin-induced peripheral neuropathy
has been previously described in mice and in neuronal cell cultures (Massicot 2013);
clinical manifestations and pathophysiological mechanisms potentially involved have also
been described in humans (Andreas 2007) (Attal 2009).
The investigators team plans to conduct a translational clinicobiological research to
explain the nature of the biochemical and molecular mechanisms of the development of
oxaliplatin-induced painful neuropathy. To perform this project, the investigators propose
to realize a pilot study in patients newly treated with oxaliplatin. This will be conducted
in the oncology department of Paris Saint Joseph Hospital from May 2014 until the inclusion
of 20 patients.
The main objective of this pilot study is to evaluate the occurrence of acute and chronic
neuropathic pain occurring in patients newly treated with oxaliplatin. The characterization
of this pain is based on validated tests (Cruccu 2010).
Moreover, the biochemical changes related to oxidative stress and those related to cellular
lipid composition are characterized in these patients.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label
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