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Triple Therapy of Dexamethasone, Palonosetron, and Fosaprepitant as PONV Prevention

Postoperative Nausea and Vomiting Clinical Trial

Official title:
Comparison of Dual Therapy of Dexamethasone and Palonosetron and Triple Therapy of Dexamethasone, Palonosetron, Fosaprepitant for Postoperative Nausea and Vomiting Prevention: A Randomized Controlled Trial

Clinical Trial Summary

As a preventive for postoperative nausea and vomiting in patients undergoing laparoscopic gynecological surgery, the investigators shall investigate the efficacy of the triple therapy of dexamethasone, palonosetron, and fosaprepitant comparing to dual therapy of dexamethasone and palonosetron.

Clinical Trial Description

Intervention 1. Control group (dual therapy) study drug (placebo): normal saline 150ml Dexamethasone 5 mg palonosetron 0.075 mg, 2. Experimental group (triple therapy) Study Drug (Fosaprepitant): resolved in normal saline 150mL Dexamethasone, Palonosetron 0.075mg, ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05773950
Study type Interventional
Source Samsung Medical Center
Contact
Status Enrolling by invitation
Phase N/A
Start date August 18, 2023
Completion date March 30, 2024
View Details
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