Gynecologic Disease Clinical Trial
Official title:
Carboprost Tromethamine (Hemabate) for Resection of Fibroids-a Pilot Study
The purpose of this research study is to determine if low-dose (i.e., a fraction of what is commonly used) carboprost (Hemabate) helps facilitate fibroid removal (myomectomy).
Status | Recruiting |
Enrollment | 30 |
Est. completion date | July 2024 |
Est. primary completion date | July 2024 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Patients scheduled to undergo myomectomy with a surgeon in the division of Minimally Invasive Gynecologic Surgery - Ability to understand and the willingness to sign a written informed consent Exclusion Criteria: - If any oxytocic agents have been or will be administered prior to surgery - History of renal and/or hepatic impairment - Active cardiac disease, pulmonary disease, or pelvic inflammatory disease (PID) - Anemia (Hgb < 7g/dL), diabetes mellitus, jaundice, or epilepsy |
Country | Name | City | State |
---|---|---|---|
United States | Northwestern University - Northwestern Medicine, Lavin Family Pavilion | Chicago | Illinois |
Lead Sponsor | Collaborator |
---|---|
Northwestern University |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Does instillation of low-dose carboprost facilitate complete resection of FIGO II fibroids during hysteroscopic resection? | Pre-operative and post-operative ultrasound will be compared to measure the residual fibroid after hysteroscopic resection with carboprost installation. | Pre-operatively to 1 month post-operatively | |
Secondary | To quantitatively assess the efficiency of fibroid resection after carboprost administration by analyzing the video recording from surgery | Recordings of all gynecologic surgeries on the site are recorded. The study team members will download and de-identify recordings by removing any PHI and labeling the video with the study ID assigned to the patient by the study team. The video will be used to assess the efficiency of fibroid removal facilitated by low-dose carboprost. The amount of tissue and the time resected will be measured to determine the grams per minute compared to historical controls. | Through study completion, up to 2 years |
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