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Clinical Trial Summary

The risk of Graft-versus-host Disease(GVHD) is significantly associated with the mortality rate of patients undergoing allogeneic hematopoietic stem cell transplantation. The occurrence of GVHD increases the hospitalization rate and economic burden of patients. In order to explore better methods for controlling GVHD, we designed a clinical trial using CD25 monoclonal antibody for GVHD prevention. Our previous studies have shown that reduced-dose anti-thymocyte globulin(ATG) in the conditioning regimen can achieve the same effect as full-dose ATG. Here, we try to explore the preventive effect of CD25 antibody on acute and chronic GHVD under low-dose ATG pretreatment condition.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT06334367
Study type Interventional
Source Shandong Provincial Hospital
Contact Xiaosheng Fang
Phone 8615168889703
Email fxsh_1010@126.com
Status Not yet recruiting
Phase Phase 2
Start date March 26, 2024
Completion date March 26, 2026

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