Gut Microbiota Clinical Trial
Official title:
Predictive Value of Human Microbiome and Serological Markers for Clinical Outcome of Cerebral Hemorrhage
Objective: To explore the predictive value of characteristic disorder of intestinal flora for clinical prognosis in patients with intracerebral hemorrhage. Secondary objectives: 1) To investigate the correlation of gut microbiota and its serological indicators with imaging features and clinical neurological deficits in ICH; 2) Dynamically observe the changes of human microbiome and its serological indicators after ICH, and explore the biomarkers based on human microbiome related to disease changes.
Spontaneous intracerebral hemorrhage has brought a heavy burden to society and families. Finding biomarkers closely related to the condition of intracerebral hemorrhage is an important research direction for the prevention and treatment of intracerebral hemorrhage. However, there are few studies on the correlation between cerebral hemorrhage and microbiota. Our previous small sample study found that there were intestinal flora and SCFAs metabolism disorders in patients with hypertensive cerebral hemorrhage, and the latter was significantly related to poor prognosis. These results suggest that gut microbiota and its metabolites may become prognostic predictors and therapeutic targets for patients with intracerebral hemorrhage. However, more research evidence is still needed to confirm. Therefore, this study hypothesized that oral or intestinal flora in patients with acute cerebral hemorrhage has a certain degree of disorder and dynamic changes, accompanied by changes in serum markers, and there is a potential relationship between the changes of some microbiota-related markers and the severity and outcome of cerebral hemorrhage. Therefore, this topic proposed collection in patients with acute cerebral hemorrhage oral swabs, blood and feces or anal swab specimens, evaluate the neurological function score, imaging features and clinical outcomes, and to establish a follow-up queue, the dynamic change of cerebral hemorrhage patients after intestinal bacterial flora and condition and poor prognosis, the correlation of biomarkers new prediction and prevention of brain hemorrhage, To improve the effectiveness of prevention and treatment of cerebral hemorrhage. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT04991792 -
Effect of an Infant Formula With Synbiotics in Infants Born Via Caesarean Section
|
N/A | |
| Completed |
NCT02151825 -
Effect of a Synbiotic on the Gut Microbiota and Adiposity-related Markers in Healthy Overweight Subjects
|
N/A | |
| Completed |
NCT01545219 -
A Study of a Prebiotic, a Probiotic and a Synbiotic Upon the Gut Microbiota and Immune Response of Healthy Volunteers
|
N/A | |
| Active, not recruiting |
NCT04435548 -
Westlake Gut Microbiome Study
|
||
| Enrolling by invitation |
NCT05057039 -
The Study of Gut Microbiota in Hypertensive Patients
|
||
| Not yet recruiting |
NCT05039060 -
Modified MAC Diet and Gut Microbiota in CRC Patients
|
N/A | |
| Completed |
NCT03746158 -
Interindividual Variation in Excretion of Curcumin
|
N/A | |
| Active, not recruiting |
NCT03266055 -
Effects of Blueberry on Gut Microbiota and Metabolic Syndrome
|
N/A | |
| Completed |
NCT04960878 -
The Effect of Synbiotics on the Upper Respiratory Tract Infection
|
N/A | |
| Active, not recruiting |
NCT05607745 -
Dietary Counseling Coupled With FMT in the Treatment of Obesity and NAFLD - the DIFTOB Study
|
N/A | |
| Recruiting |
NCT04120051 -
The SIMBA Project - The Effect of a Prebiotic Supplement on Glucose Metabolism and Gut Microbiota in Obese Adults
|
N/A | |
| Not yet recruiting |
NCT05481866 -
Targeting Gut Microbiota and Metabolites for Very Preterm Infants Through Oropharyngeal Administration of Colostrum
|
N/A | |
| Completed |
NCT03293693 -
Intake of Beta-glucan and Postprandial Regulation of Blood Glucose Metabolism in Healthy Subjects
|
N/A | |
| Completed |
NCT02207140 -
Effect of Multi-species Probiotic HOWARU® Restore, on Gut Microbiota of Elderly
|
Phase 0 | |
| Recruiting |
NCT04203459 -
The Mechanism of Enhancing the Anti-tumor Effects of CAR-T on PC by Gut Microbiota Regulation
|
||
| Active, not recruiting |
NCT03259685 -
Effect of Non-nutritive Sweeteners of High Sugar Sweetened Beverages on Metabolic Health and Gut Microbiome
|
N/A | |
| Recruiting |
NCT06157346 -
Characteristics of Intestinal Bacteria and Their Effects on Growth and Immune Function in Children at High Altitude
|
||
| Completed |
NCT03203044 -
Impact of Soylent Consumption on Human Microbiome Composition
|
N/A | |
| Recruiting |
NCT05975541 -
Susceptibility to Infectious Diseases in Obesity
|
||
| Active, not recruiting |
NCT05457439 -
Sustainable-psycho-nutritional Intervention Program and Its Effects on Health Outcomes and the Environment
|
N/A |