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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT04399434
Other study ID # SAHoWMU-CR2020-07-209
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date January 1, 2019
Est. completion date October 1, 2020

Study information

Verified date May 2020
Source Second Affiliated Hospital of Wenzhou Medical University
Contact Ying Hua
Phone +8613676403165
Email wzfeyhy1015@126.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Abnormal fetal size includes fetal growth restriction and fetal macrosomia. Onset is closely related to maternal nutrition metabolism. The specific correlation and mechanism is unclear, and there are no effective measures for early diagnosis and treatment. Previous study found that maternal gut microbiota participates in the material metabolism throughout the pregnancy. Insulin sensitivity in pregnant women, and intrauterine environment under abnormal blood glucose and lipid metabolism are important for the gut microbiota of newborns and even they grow up. However, changes in gut microbiota are the cause of the disease or the outcome is not yet clear. Short chain fatty acids (SCFAs) are produced from soluble dietary fibers in the diet by colon bacteriolysis. Studies have found that gut microbiota can regulate insulin sensitivity and glucose and lipid metabolism disorders through SCFAs. Therefore, this research group uses the gut microbiota as a new idea to studythe relationship of gut microbiota characteristics and level's change of SCFAs with glucolipid metabolism and insulin sensitivity in pregnant women with abnormal fetal size and their newborns through 16S-rRNA high-throughput sequencing, pyrosequencing, and gas chromatography-mass spectrometry, so we can reveal the role of gut microbiota in the pathogenesis of abnormal fetal size and explore targeted rational dietary adjustment and SCFAs reconstruction of gut microbiota to improve maternal and neonatal pregnancy outcomes.


Recruitment information / eligibility

Status Recruiting
Enrollment 120
Est. completion date October 1, 2020
Est. primary completion date August 1, 2020
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Female
Age group 18 Years to 40 Years
Eligibility Inclusion Criteria:

- Singleton pregnancy

- Term pregnancy with the gestational age of 37-40 weeks

Exclusion Criteria:

- Maternal systemic diseases (hypertension disorders, immunological diseases) or pregnant complications (polyhydramnios, oligohydramnios, diabetes mellitus, intrahepatic cholestasis of pregnancy)

- Delivery before 37 weeks or after 40 weeks

- Neonates had major congenital malformations (congenital anal atresia, congenital biliary atresia, congenital heart disease)

Study Design


Intervention

Other:
test gut microbiota, SCFAs and glucolipid metabolism and insulin sensitivity
test gut microbiota and SCFAs in mothers and their newborns and glucolipid metabolism and insulin sensitivity in mothers

Locations

Country Name City State
China department of obstetrics of Second Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang

Sponsors (1)

Lead Sponsor Collaborator
Second Affiliated Hospital of Wenzhou Medical University

Country where clinical trial is conducted

China, 

Outcome

Type Measure Description Time frame Safety issue
Primary Gut Microbiota and SCFAs in mothers and their newborns Collect the DNA of fecal flora to test the diversity and abundance of gut microbiota as well as short chain fatty acids in Stool samples Stool samples from pregnant women with 37-40 gestational week and newborns within 3 days after birth
Primary glucolipid metabolism and insulin sensitivity in pregnant women glucolipid metabolism and insulin sensitivity in pregnant women with normal and abnormal fetal size Blood samples from pregnant women with 37-40 gestational week
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