Gut Microbiome Clinical Trial
Official title:
The Effects of Cocoa-rich Bioflavanol Supplementation on Manual Dexterity During Cold Exposure
The primary purpose is to test whether cocoa-rich bioflavanols can improve blood flow to the hand and fingers and improve hand function/dexterity during cold exposure. Secondary purpose is to understand whether bioflavanol supplementation can change the gut microbiome.
Status | Recruiting |
Enrollment | 40 |
Est. completion date | September 2021 |
Est. primary completion date | May 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 49 Years |
Eligibility | Inclusion Criteria: - Age - 18-49 years (17-49 for active military). - Refrain from the following for 2 weeks before and during the study (including the washout period): consumption of flavanol rich foods including cocoa, chocolate, apples, red, white, and sweet wine, apricots, blueberries, peaches/nectarines, plums, grapes, strawberries, pecans (no more than ½ cup/day, pistachios, (no more than ½ cup per day), and apple juice. - Participants not to change their daily intakes of tea (green or black) or coffee. Exclusion Criteria: - History of cold injuries. - Raynaud's syndrome. - Cold-induced asthma/bronchospasm - Difficulty swallowing pills. - Previous hand/finger injuries that impair dexterity and hand function. - Metal hardware (plates/screws) in the forearms and hands. - Blood donation in last 8 weeks. - Medicine use (including any over the counter medication such as Tylenol, Advil, Sudafed, etc…), with the exception of birth control and a multi-vitamin. - Known allergies to medical adhesives or cocoa/chocolate. - History of disease of the gastrointestinal tract including (but not limited to) diverticulosis, diverticulitis and inflammatory bowel disease, peptic ulcer disease, Crohn's disease, ulcerative colitis; or previous gastrointestinal surgery. - No planned MRI during the study or within 2 days after completing a cold test. - Use of dietary supplements (to include probiotics and prebiotics), with exception of multi-vitamin containing up to 100% of the recommended daily allowance (RDA). - No exercise or smoking within 8 hours of testing. - Pregnant or breastfeeding. - Oral antibiotic use within 3 months of study participation. - Inability or unwillingness to not consume fermented food products or prebiotic-containing food products for 2 weeks prior to and throughout study participation. Examples include kefir, kombucha, aged cheese, pickles, sauerkraut, sour cream, tempeh, yogurt, kimchi, miso, vinegar, sourdough bread, wine and beer. - Colonoscopy within 3 months of study participation. - On average has a bowel movement less frequently than every other day. |
Country | Name | City | State |
---|---|---|---|
United States | John W Castellani | Natick | Massachusetts |
Lead Sponsor | Collaborator |
---|---|
United States Army Research Institute of Environmental Medicine |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Cold induced vasodilation response | Skin/finger temperature changes during finger immersion in 4°C water | 30 minutes | |
Primary | Manual dexterity-PP | Purdue Pegboard score during 8°C air exposure. Score is the number of pegs placed into board. | 2 hours | |
Primary | Manual dexterity-MRM | Minnesota Rate of Manipulation dexterity score during 8°C air exposure. Score is the number of pieces put together during times period. | 2 hours | |
Primary | Hand and finger temperatures | Hand and finger temperatures during cold air exposure in 8 | 2 hours | |
Secondary | Gut microbiome | How do targeted populations (Bifidobacterium spp., Lactobacillus spp., C. coccoides-Eubacterium rectale, Faecalibacterium prausnitzii, Prevotella/Bacteroides, Roseburia, and Akkermansia muciniphila) change as a result of bioflavanol supplementation | 8 days |
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