Gut Microbiome Clinical Trial
Official title:
The Gut Microbiome and Metabolic Activity in Patients With Vitiligo
Vitiligo is a chronic depigmenting autoimmune-associated skin disease and a growing psychological health concern because of its low quality of life. Genetics, immunology and environment triggers contribute to the pathophysiology of vitiligo. Identify and decrease the risk factors of vitiligo is very crucial for vitiligo treatment and prevention. Emerging evidence has linked gut microbiome to human autoimmune diseases. Here the investigators will analyze 10,913 metagenomes in stool samples from 100 adult vitiligo patients and gut microbiome associated metabolites in patients serum.
Vitiligo, an autoimmune disease of the skin, is a commonly acquired chronic depigmenting
disorder characterized by loss of epidermal melanocytes and progressive depigmentation
clinically, affecting from 0.5% to 1% of the world population and about 1% in China Vitiligo
can be a psychologically crushing associated with low quality of life, especially in colored
skinned individuals. The pathoetiology of vitiligo is multifactorial and has genetic,
immunological, and environmental components. Several environment-associated mechanisms have
been implicated to explain melanocyte disappearance, including ultraviolet (UV) radiation
exposure, repeated mechanical or thermal stress, and exposure to chemicals (especially
phenols or catechols), but epidemiologic data remain limited.
Broader gut dysbioses have been identified as potential causes or contributing factors to
human autoimmune diseases; however, human studies have not yet identified microbial
compositional or functional triggers that are predictive of skin autoimmunity or vitiligo.
Metabolites from intestinal microbiota are key determinants of host-microbe mutualism and,
consequently, the health or disease of the intestinal tract. However, whether such
host-microbe crosstalk influences inflammation in peripheral tissues, such as the skin, is
poorly understood.
The investigators will perform a metagenome association study and serum metabolomics
profiling in a cohort of vitiligo Chinese individuals.
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