Microbiota Clinical Trial
Official title:
Probiotics After Discharge (PAD) Study: Impact on Microbiome, Health and Growth Outcomes
The influence of the preterm gut microbiota in health and disease has been well established.
However, relatively little is known about how the microbiome changes after discharge and its
relationship with growth, health and disease outcomes in the preterm population. This study
aims to follow a cohort of preterm infants and explore the relationship of the later
microbiome ('after discharge') with later growth and health outcomes in infancy. The study
will also explore the effect of timing of stopping routinely administered probiotics on the
post-discharge microbiome, infant feeding and outcomes such as colic.
The investigators aim to longitudinally follow 40 infants born before 32 weeks gestation who
have also taken part in the investigators microbiome study during their NICU stay (SERVIS REC
No: 10/H0908/39) and where microbiomic sampling has been adequately achieved. The
investigators will collect stool at and beyond the time of anticipated discharge (beyond 34
weeks) targeted to include pre- and post-weaning, and again at a year. Actual discharge
timing of these infants varies, and is usually latest in the most immature infants, allowing
an assessment of the influence of physical location (NICU vs home) as well as increasing age.
Using 16S ribosomal RNA amplicon analysis, the investigators will assess bacterial
colonisation of the gut and measure infant weight, length and head circumference at each time
point. The investigators will use a parent questionnaire to assess daily crying time,
parents' perceptions of colic severity using a visual analogue scale as well as vomiting and
constipation for the two weeks before sampling.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Withdrawn |
NCT03239197 -
Project SHARE (motherS Have All the Right microbEs)
|
N/A | |
| Completed |
NCT04117802 -
Effects of Maple Syrup on Gut Microbiota Diversity and Metabolic Syndrome
|
N/A | |
| Recruiting |
NCT05941663 -
Microbiome Development in the Early Healing of Osseointegrated Implants
|
N/A | |
| Recruiting |
NCT06144905 -
Norwegian Microbiota Study in Anorexia Nervosa
|
||
| Active, not recruiting |
NCT05864352 -
The Role of Dietary Titanium Dioxide on the Human Gut Microbiome and Health
|
||
| Recruiting |
NCT04138979 -
Intestinal Microbiota of Breast Cancer Patients Undergoing Chemotherapy
|
||
| Recruiting |
NCT04132713 -
Study on Skin Microbiome of HFS
|
||
| Completed |
NCT05726435 -
Effects of Soluble Dietary Fiber on Sport Efficiency and Fatigue Delay in Top Basketball Players
|
N/A | |
| Completed |
NCT03543891 -
Intestinal Microbiota and Thyroid Cancer
|
||
| Completed |
NCT05242913 -
Effects of Resistant Potato Starch on the Gut Microbiota
|
N/A | |
| Recruiting |
NCT04200521 -
The Effect of Bariatric Procedures on Gut Microbiota in Obese Individuals in United Arab Emirates and Lebanon
|
||
| Recruiting |
NCT05891977 -
Effect of Tomato Paste Consumption on the Microbiota-gut-brain Axis in Healthy Adults
|
N/A | |
| Completed |
NCT02988349 -
Ecological Effect of Arginine Dentifrice on Oral Microbiota
|
N/A | |
| Completed |
NCT05352724 -
Clinical Trial to Evaluate the Efficacy of a Sport Drink After High-intensity Aerobic Exercise
|
N/A | |
| Completed |
NCT04674839 -
The Impact of MS-20 on Gut Microbiota Composition in Adult Individuals
|
N/A | |
| Completed |
NCT03754504 -
Effects of Cranberry Powder Supplements on Gut Microbiota Diversity and Metabolic Syndrome
|
N/A | |
| Completed |
NCT05394948 -
Circular Economy and the Design of Healthy and Sustainable Food and Ingredients
|
N/A | |
| Terminated |
NCT03752372 -
Microbiome Alterations in IL10RA-deficient Patients After HSCT
|
||
| Completed |
NCT05974124 -
Effectiveness of Ophthalmic Antiseptic Preparations
|
N/A | |
| Recruiting |
NCT02005003 -
Cognitive and Metabolic Effects of a Probiotic Supplement
|
N/A |