Growth Hormone Treatment Clinical Trial
Official title:
More Favorable Metabolic Impact of Three-times-weekly Versus Daily Growth Hormone (GH) Treatment in naïve GH-deficient Children
Growth hormone (GH) treatment in patients with GH deficiency (GHD) is commonly administered daily, although the pulsatile GH secretion is unlikely to be achieved and this regimen is often not complied. The auxological effect of three injections per week (TIW) regimen is controversial, while the metabolic effects were never evaluated in children. The objective of this study was to evaluate whether two different regimens of weekly injections could lead to similar auxological and metabolic effects in children with GHD.
Thirty-two children with growth hormone (GH) deficiency (25 males, mean age 10.5 ± 2.2 yr)
were randomly assigned to receive daily (group A, No 16) or three injections per week (group
B, No 16) GH therapy for 12 months.
Auxological parameters, insulin-like growth factor-I (IGF-I), glucose and insulin during an
oral glucose tolerance test, glycosylated hemoglobin, lipid profile, the oral disposition
index (DIo), the homeostasis model assessment estimate of insulin resistance (Homa-IR), the
quantitative insulin sensitivity check index (QUICKI) and the insulin sensitivity index (ISI)
were evaluated in the two groups of patients.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT02987868 -
Effects of an Amino Acid-Based hGH Secretagogue on Triiodythyronine
|
N/A | |
Recruiting |
NCT03431727 -
Acromegaly - Before and After Treatment
|
||
Completed |
NCT03038594 -
Growth Hormone Therapy for Muscle Regeneration in Severely Burned Patients
|
Phase 2/Phase 3 | |
Completed |
NCT02782221 -
Lipolytic Effects of GH in Human Subjects in Vivo
|
N/A | |
Completed |
NCT03203356 -
Adrenal Function in GHD Children
|
N/A | |
Completed |
NCT05195437 -
Evolution of the Quality of Life of Short Statured Children Treated With Growth Hormone : Evaluation at Adult Size
|
||
Completed |
NCT05105685 -
Effectiveness of Recombinant Human Growth Hormone Therapy for Children With PMS
|
Phase 1/Phase 2 | |
Completed |
NCT04244123 -
Web-based Adherence Information Integrated Nurse-led Monitoring Clinic
|
||
Not yet recruiting |
NCT03005561 -
Detection of Difficulties and Improvement Compliance to Growth Hormone Treatment
|
N/A | |
Recruiting |
NCT06448195 -
Effects of Growth Hormone Therapy on Metabolic Function in Fatty Liver Post-Pituitary Adenoma Surgery
|
Phase 4 | |
Not yet recruiting |
NCT05660356 -
Growth Hormone Deficiency in Mild Traumatic Brain Injury
|
Early Phase 1 | |
Active, not recruiting |
NCT00867971 -
Is Recombinant Growth Hormone Therapy Associated With Increased Intraoccular Pressure?
|
N/A | |
Recruiting |
NCT05253287 -
Growth Hormone in Decompensated Liver Cirrhosis
|
Phase 2/Phase 3 | |
Active, not recruiting |
NCT03091374 -
Impact of Recombinant Human Growth Hormone on HIV Persistence
|
Phase 2 | |
Not yet recruiting |
NCT02326610 -
Early hGH Treatment of SGA Infants to Prevent Irreversible Neurologic and Psychological Damage and Sequelae
|
Phase 2 | |
Recruiting |
NCT06103513 -
Randomized Clinical Trial of Two Different Initial Growth Hormone Doses in Children
|
Phase 3 | |
Recruiting |
NCT04938466 -
Assessment of Adherence, Quality of Life, Clinical Response and Safety of Daily and Long-Acting Growth Hormone Therapy
|
||
Recruiting |
NCT06037473 -
The Efficacy and Safety of PEGylated GH for the Treatment of Short Stature in Chinese Children-GLOBE Reg
|
||
Recruiting |
NCT05144035 -
A Real World Study of the Effect of Early PEG-rhGH Therapy on Cognitive Development of SGA Infants
|
Phase 4 | |
Recruiting |
NCT03878992 -
Effects of Growth Hormone and IGF-1 on Anabolic Signals and Stem Cell Recruitment in Human Skeletal Muscle
|
N/A |