Growth Hormone Deficiency Clinical Trial
Official title:
The Effect of Growth Hormone (GH) on Intramyocellular Lipids (IMCL), Intrahepatocellular Lipids (IHCL) and Visceral Fat Mass in Relation to Insulin Resistance
This study aims at investigating the effect of growth hormone on lipid-content of muscle and
liver as well as visceral fat mass in relation to insulin sensitivity.
In addition, hormonal regulation and free fatty availability is assessed during a physical
exercise at 50-60% VO2max.
Finally, the value of physical exercise in diagnosing growth hormone deficiency is
investigated.
Hypothesis: 1) Lipid content of muscle and liver change with physical exercise and exercise
capacity and free fatty availability will influence these changes. 2)Growth hormone
replacement therapy will predominantly reduce visceral fat mass and increase free fatty
availability.
3)Free fatty availability during exercise will be reduced in growth hormone deficient
patients 4)Physical exercise may be an alternative way to diagnose growth hormone deficiency
Using the two-step hyperinsulinaemic-euglycaemic clamp technique hepatic and peripheral
insulin sensitivity is assessed.
Lipid depots (skeletal muscle and liver) are measured by MR-spectroscopy, visceral fat mass
by MR-imaging.
Exercise capacity ist measured on a treadmill. Counterregulatory hormones, glucose and free
fatty acids are measured during a 2h physical exercise at 50-60 VO2max Identical
investigations are performed in adult growth hormone (GH) deficient patients before and
after six months GH replacement therapy, in sedentary matched control subjects and in
endurance trained athletes.
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Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
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