Metabolic Syndrome Clinical Trial
Official title:
The Effect of Milk and Meat on IGFs in Prepubertal Boys
The objective of the study is to examine whether a 7-day high protein intake from either milk or meat in healthy, prepubertal children can increase fasting levels of serum IGF-I, IGFBP-3 and IGF-I/IGFBP-3 as well as insulin, glucose and HOMA insulin reststance, HOMA beta cell function and amino acids.
The objective of the study is to examine whether a high protein intake (PI) from either milk
or meat, at a level often seen in late infancy, in healthy, prepubertal children can
increase fasting levels of serum IGF-I, IGFBP-3 and IGF-I/IGFBP-3 as well as insulin,
glucose and HOMA insulin reststance, HOMA beta cell function and amino acids.
IGF-I levels are positively associated with growth velocity in children and some studies
suggest that a high animal PI can stimulate growth. During protein deprivation IGF-I
decrease, but it is unknown whether a high PI can increase s-IGF-I in well-nourished
children.
Insulin is also a growth factor, and studies have found that postprandially, milk possess
some insulinotrophic effect not related to its carbohydrate content. However, the effect on
fasting insulin in children is unknown.
Design: Twenty-four 8-y-old boys are asked to take either 1.5 l of skimmed milk (n=12) or
the same amount of protein as 250 g low fat meat (n=12) daily for seven days. The remaining
diet they can choose freely. At baseline and after seven days, anthropometrical variables
are measured, diet is registered (3-d weighed records), and the blood analytes are
determined after fast.
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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