Group B Streptococcus Clinical Trial
Official title:
Attitudes to Immunisation Against Group B Streptococcus During Pregnancy in England and Scotland
Group B Streptococcus (GBS) is the commonest cause of severe infection and meningitis in
babies under 3 months in the United Kingdom (UK). About one in ten babies with GBS infection
die and half of babies with GBS meningitis are left with long term problems with their
development.
Vaccinating pregnant women against GBS in order to protect their newborn babies is a
promising area of research.However, many women are reluctant to accept vaccination during
pregnancy for fear it will harm their unborn child and there is often a lack of understanding
of both the vaccine and the condition it aims to prevent. Nevertheless, the recent positive
experience of immunisation against pertussis in the United Kingdom, suggest that antenatal
immunisation can be acceptable.
Previous research has shown that advice from maternity healthcare professionals regarding
vaccination is highly valued by pregnant women so it is also important to explore the
attitudes and opinions of this group.
The objective of this study is to assess the knowledge and attitudes of pregnant women and
maternity healthcare professionals in England and Scotland regarding GBS disease and the
acceptability of a potential vaccine.
There are two parts to this study. The first part will invite pregnant women, maternity
healthcare professionals and parents who have had a child affected by GBS disease to take
part in either a focus group or an individual interview.
This will allow for an in-depth exploration of the participants thoughts and opinions about
GBS and vaccination in pregnancy. This part of the study will take place at the Oxford site
only. The results will guide the development of a self completed, paper questionnaire which
will be distributed to a wider range of pregnant women and maternity healthcare professionals
across four different study sites.
This study has been funded by Meningitis UK. Additional collaborators to those listed include
the charity Group B Strep Support.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04059510 -
Developing a Controlled Human Infection Model for Group B Streptococcus (CHIM_GBS)
|
||
| Completed |
NCT01150123 -
Safety and Immunogenicity of a Group B Streptococcus Vaccine in Healthy Women
|
Phase 1 | |
| Completed |
NCT02511444 -
Intrapartum Rapid GBS Testing in Patients Presenting With Threatened Preterm Labor
|
N/A | |
| Completed |
NCT00716781 -
Management of Infants Born to Group B Streptococcus Positive Mothers.
|
N/A | |
| Active, not recruiting |
NCT00972894 -
Group B Streptococcus (GBS) Polymerase Chain Reaction (PCR) Concordance Study
|
N/A | |
| Terminated |
NCT00823433 -
Oral Penicillin and Penicillin Levels in Venous Umbilical Cord Blood
|
Phase 0 | |
| Completed |
NCT01251289 -
The Prevalence of Group B Streptococcus Positive Pregnant Patients in an Inner City Tertiary Care Center
|
||
| Completed |
NCT01180023 -
Membrane Sweeping in Group B Streptococcus (GBS) Positive Patients
|
N/A | |
| Completed |
NCT00008853 -
Evaluation of Two Type III GBS Polysaccharide-Tetanus Toxoid Conjugate Vaccines
|
Phase 1 |