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A Study to Evaluate the Efficacy and Safety of LASN01 in Patients With Thyroid Eye Disease

Eye Diseases Clinical Trial

Official title:
A Phase 2, Proof-of-Concept, Randomized, Double-Masked, Placebo-Controlled Study to Determine the Efficacy and Safety of LASN01 in Patients With Thyroid Eye Disease

Clinical Trial Summary

LASN01 is a novel, fully human antibody directed against the human IL-11 receptor being developed for treatment of patients with thyroid eye disease (TED). The primary and secondary objectives of this study are to evaluate the safety, efficacy, and pharmacokinetics of LASN01 administered IV in patients with TED with no prior anti-IGF-1R treatment or in patients with TED who have previously received teprotumumab treatment.

Clinical Trial Description

This clinical trial (LASN01-CL-2201) comprises a multiple-dose design in 3 parallel treatment arms for patients with TED with no prior anti-IGF-1R treatment, and a 4th treatment arm for patients with TED who have previously received teprotumumab treatment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06226545
Study type Interventional
Source Lassen Therapeutics Inc.
Contact Lassen Therapeutics
Phone +1 858 251 7528
Email cl-2201@lassentherapeutics.com
Status Recruiting
Phase Phase 2
Start date March 5, 2024
Completion date March 2025
View Details
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