Hydroxychloroquine in Mild Graves' Orbitopathy

Status Recruiting

Clinical Trial Summary

This study is aimed to investigate the effect of hydroxychloroquine in patients with mild Graves' orbitopathy (GO).

Clinical Trial Description

Graves' orbitopathy (GO) is one of the common manifestations of Graves' disease (GD), which results in proptosis, eyelid retraction, soft tissue swelling, diplopia or even visual acuity impairment. In addition, mental health and quality of life are often affected. In current guidelines, limited treatment options are suggested for patients with mild GO. Recently, cell study revealed that there are multiple effects of hydroxychloroquine (HCQ) on orbital fibroblasts in patients with mild GO, including suppression of cell proliferation, adipogenesis and production of hyaluronic acid, which poses a great potential in the treatment of mild GO clinically. This randomized controlled trial is aimed to investigate the effects of HCQ in patients with mild GO on the effects of ophthalmic outcomes, quality of life, orbital volumetry on orbital computed tomography, serum inflammatory and fibrosis markers. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05126147
Study type	Interventional
Source	National Taiwan University Hospital
Contact	Shyang-Rong Shih
Phone	+886-2-23123456
Email	srshih@ntu.edu.tw
Status	Recruiting
Phase	Phase 4
Start date	March 21, 2022
Completion date	December 31, 2024

View Details

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