Comparative Study of Different I-131 Doses in Graves' Disease

Status Recruiting

Clinical Trial Summary

Radioactive iodine (RAI) administration is an effective and completely established treatment modality in hyperthyroidism including Graves' disease. Despite the long experience with radioiodine for hyperthyroidism, controversy remains regarding the optimal dose of iodine that is required to achieve long-term euthyroidism. The fixed activity administration method does not optimize the therapy, giving often too high or too low radiation to the gland, but the optimal dose per gram of thyroid mass in calculated activity administration method is also under much debates. This prospective study has been designed in order to compare the effect of different calculated doses of radioiodine on Graves' disease treatment outcome.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02114619
Study type	Interventional
Source	Mashhad University of Medical Sciences
Contact	Seyed Rasoul Zakavi, MD. IBNM
Phone	+98-511 8012799
Email	Zakavir@mums.ac.ir
Status	Recruiting
Phase	N/A
Start date	May 2013
Completion date	December 2016

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See also
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