Grass Pollen Allergic Rhinitis Clinical Trial
Official title:
Resolution of Allergic Inflammation: Identification and Kinetics of Specific Lipid Mediators During Nasal Allergen Challenge
After an allergen challenge, the allergic inflammatory response disappears spontaneously. The initiation of the resolution of the inflammatory response is now recognized as a dynamic process, involving active biochemical programs that enable inflamed tissues to return to homeostasis. Recent data established key roles of different specific lipid mediators in the endogenous counter-regulation of inflammation and activation of resolution. Only little is known about kinetics of these specialized pro-resolving lipid mediators during acute allergic inflammation. Therefore, the primary propose of our study is to characterize the temporal evolution of cellular inflammation and specific lipid mediators after allergen challenge.
| Status | Completed |
| Enrollment | 20 |
| Est. completion date | April 2014 |
| Est. primary completion date | April 2014 |
| Accepts healthy volunteers | No |
| Gender | Both |
| Age group | 18 Years to 55 Years |
| Eligibility |
Eligibility criteria: Inclusion Criteria - Allergic rhinitis during the grass pollen season with or without asthma, with at least one of the following symptoms: nasal congestion, itching, rhinorrhea, sneezing - Grass pollen sensitization determined by a positive skin prick test and / or presence of specific IgEs to a grass pollen allergen extract Exclusion Criteria: - Smoker - Specific immunotherapy with grass allergens or other respiratory allergen for inclusion. - Current exhibition to another clinically relevant respiratory allergen |
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject)
| Country | Name | City | State |
|---|---|---|---|
| France | Hôpitaux Universitaires | Strasbourg |
| Lead Sponsor | Collaborator |
|---|---|
| University Hospital, Strasbourg, France |
France,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Clinical nasal score and measurement of mediators in biological fluids | Measurement of mediators in biological fluids during 72 h after nasal allergen challenge | No | |
| Primary | Clinical nasal score and measurement of mediators in biological fluids. | Measurement and indentification of specific lipid mediators during nasal allergen challenge |