Bacteremia Clinical Trial
Official title:
Epidemiology, Outcomes, and Costs Associated With Gram Negative Bacteremia
This study examines the clinical outcomes and healthcare costs associated with gram negative bacteremia at Duke University Medical Center from 2002-2015.
Specific Aim 1: Define the clinical impact of gram negative bacterial (GNB) bloodstream
infections (BSI). In this objective, the investigators will describe the prevalence, source
of bacteremia, and location of acquisition (i.e., community-acquired, healthcare-associated,
hospital-acquired) of GNB BSI. The investigators will also examine the outcomes associated
with GNB BSI including length of hospital stay, length of ICU stay, in-house mortality, and
hospital costs.
Specific Aim 2: Describe antibiotic resistance patterns in GNB BSI, and explore associations
between antibiotic resistance and clinical and economic outcomes. In this objective, the
investigators will describe the prevalence and antibiotic susceptibility profiles of
multidrug resistant phenotypes including MDR bacteria, which are defined by resistance to
three or more drug classes, ESBL-producers, and CRE. The investigators will examine the
differences in mortality, resource use (length of hospital stay, length of ICU stay), and
direct medical costs between cases with and without antibiotic resistance.
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Observational Model: Cohort, Time Perspective: Prospective
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