Graft Vs Host Disease Clinical Trial
Official title:
Analysis of Transcriptomic Profile of Graft-versus-host Disease (GHVD) After Allogeneic Grafting of Hematopoietic Stem Cells
Graft-versus-host disease (GVHD) is a frequent and severe complication of hematopoietic stem
cell transplantation (HSC), and is responsible for significant early mortality despite
prophylactic strategies developed in recent decades, Especially since it is resistant to
first-line treatment.
The present diagnosis is difficult, non-specific and is based on the combination of an
evocative clinical context (CSH allograft, time to appearance before J100, characteristic
clinical manifestations), suggestive anatomo-pathological analysis (predominantly
inflammatory infiltrate Lymphocyte, mucosal edema and presence of apoptotic bodies), and the
exclusion of any differential diagnosis (in particular serology / negative viral PCR).
However, to date there is no molecular characterization of this manifestation, and therefore
no specific treatment.
The nCounter® nanostring technology allows the rapid and simple analysis of the simultaneous
expression of a group of genes (up to 800 on the same sample), from a very small amount of
RNA, and from samples with difficulty Such as fabrics already fixed to formaldehyde and
included in paraffin. It allows the detection of a "molecular signature" of the tissue
analyzed.
No transcriptomic analysis has ever been performed on human tissues with GVHD.
n/a
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