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A Study to Evaluate the Safety, Tolerability, and Activity of KD025 in Subjects With Chronic Graft Versus Host Disease

Graft vs Host Disease Clinical Trial

Official title:
A Phase 2a, Dose-Escalation, Open-Label Study to Evaluate the Safety, Tolerability, and Activity of KD025 in Subjects With Chronic Graft Versus Host Disease

Clinical Trial Summary

This study was been conducted to evaluate the safety, tolerability, and activity of belumosudil (formerly known as KD025) in adult participants with chronic graft versus host disease (cGVHD).

Clinical Trial Description

Fifty four (54) participants were enrolled to receive orally administered belumosudil 200 milligrams (mg) once daily (QD), belumosudil 200 mg twice daily (BID), or belumosudil 400 mg QD. Study drug was administered in 28-day cycles until disease progression or occurrence of unacceptable toxicity. Participants received study drug in the inpatient or outpatient setting. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02841995
Study type Interventional
Source Sanofi
Contact
Status Completed
Phase Phase 2
Start date September 15, 2016
Completion date May 12, 2022
View Details
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