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Grade IV Astrocytoma clinical trials

View clinical trials related to Grade IV Astrocytoma.

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NCT ID: NCT04606316 Active, not recruiting - Glioblastoma Clinical Trials

Surgical Nivolumab And Ipilimumab For Recurrent GBM

Start date: February 1, 2021
Phase: Phase 1
Study type: Interventional

This research trial is studying the safety and effectiveness of nivolumab in combination with ipilimumab and surgery when used in the treatment of recurrent glioblastoma. The names of the study drugs involved in this study are: - Nivolumab - Ipilimumab - Placebo (IV solution with no medicine) - Zr-89 Crefmirlimab berdoxam (optional sub-study)

NCT ID: NCT00045968 Active, not recruiting - Glioblastoma Clinical Trials

Study of a Drug [DCVax®-L] to Treat Newly Diagnosed GBM Brain Cancer

GBM
Start date: December 2006
Phase: Phase 3
Study type: Interventional

The primary purpose of the study is to determine the efficacy of an investigational therapy called DCVax(R)-L in patients with newly diagnosed GBM for whom surgery is indicated. Patients must enter screening at a participating site prior to surgical resection of the tumor. Patients will receive the standard of care, including radiation and Temodar therapy and two out of three will additionally receive DCVax-L, with the remaining one third receiving a placebo. All patients will have the option to receive DCVax-L in a crossover arm upon documented disease progression. (note: DCVax-L when used for patients with brain cancer is sometimes also referred to as DCVax-Brain)