Defining Decision Thresholds for Judgments on Health Benefits and Harms: Study Protocol

Decision Support Techniques Clinical Trial

Official title: Defining Decision Thresholds for Judgments on Health Benefits and Harms Using the GRADE Evidence to Decision (EtD) Frameworks: Protocol for a Randomized Methodological Study (GRADE-THRESHOLD)

Status Recruiting

Clinical Trial Summary

The objective of this study is an approach to derive and use decision-thresholds for judgments on health benefits and harms using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Evidence to Decision (EtD) frameworks.

Clinical Trial Description

The objective of this study is to derive decision-thresholds (DTs) for Evidence to Decision (EtD) judgments on the magnitude of health benefits and harms. The study hypothesis is that DTs could discriminate between the four categories for EtD judgments. Explicit DTs, providing an indication for which could be the appropriate judgment for a given scenario, might have the potential to support panels of decision-makers in their work, facilitate a common understanding, and promote consistency and transparency in judgments.

Study investigators will conduct a methodological randomized controlled trial to collect the data that allow deriving the decision-thresholds. They will invite clinicians, epidemiologists, decision scientists, health research methodologists, experts in Health Technology Assessment (HTA), members of guideline development groups and the public to participate in the trial. Then, investigators will investigate the validity of decision-threshold by measuring the agreement between judgments that were made in the past by guideline panels and the judgments that the DTs approach would suggest if applied on the same guideline data. ;

Related Conditions & MeSH terms

• Decision Support Techniques
• GRADE Approach

• NCT number: NCT05237635
• Study type: Interventional
• Source: McMaster University
• Contact: Holger J Schunemann, MD, PhD
• Phone: +19055259140
• Email: schuneh@mcmaster.ca
• Status: Recruiting
• Phase: N/A
• Start date: June 9, 2020
• Completion date: December 31, 2022