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Clinical Trial Summary

The main objective is to describe urate deposits (especially in terms of distribution and volume) in soft tissues and bone, and joint erosions and destruction, in adult patients with gout.


Clinical Trial Description

Gout is the result of hyperuricemia, itself a consequence of a disorder of purine metabolism. This hypuricemia can lead to the deposition of sodium urate crystals in the soft tissues. It is the deposition of sodium urate crystals in and near the joints that causes an intense local inflammatory reaction with episodes of acute joint pain, swelling and functional disability. In the long term, uratic concretions in the soft tissues (tophus) occur, the joints are destroyed (uratic arthropathies), the kidneys also (gouty nephropathy). Dual-energy CT (Computed Tomography) is a relatively recent technique that allows the identification of certain materials through the analysis of the difference in attenuation of the material exposed to two different X-ray spectra. This technique identifies the crystalline component of tophus. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05065606
Study type Observational
Source Assistance Publique - Hôpitaux de Paris
Contact Valérie BOUSSON, PUPH
Phone +33(0)149959107
Email [email protected]
Status Recruiting
Phase
Start date November 30, 2016
Completion date November 30, 2021

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