Gout Clinical Trial
Official title:
Effects of Green Tea on Level of Serum Uric Acid in Healthy Individuals
Green tea has been extensively investigated for several potential health benefits. Previous studies have suggested that green tea may lower serum uric acid level in human. The purpose of this study is to investigate uric-lowering properties of green tea in healthy individuals.
Elevated serum uric acid is related to the risk of development of gout, the most common
inflammatory arthritis in men. Allopurinol, a xanthine oxidase inhibitor, is one of the
uric-lowering agents commonly used in patients suffering from recurrent and chronic gout.
Nevertheless, its use is limited by adverse effects and serious allergic reaction in some
patients.
Green tea is one of the most frequently consumed beverages, particularly in Japan. Green tea
contains high level of catechins, in which Epigallocatechin gallate (EGCG) is the most
abundant compound among other types of catechins. Antioxidant effect contributes to various
potential health benefits of green tea. Several in-vitro studies have found that green tea
inhibits xanthine oxidase activity and subsequently decreases reactive oxygen species (ROS)
and uric acid production. We therefore would like to investigate the hypouricemic effects of
green tea.
The study consists of three periods with a total duration of four weeks. The first week is
the control period. The following two weeks is the interventional period and the last week
is the follow up period. Thirty healthy participants will be randomly assigned into three
experimental groups, receiving 2 gm/day, 4 gm/day and 6 gm/day (in capsule, two times after
meal) of green tea extract during interventional period. Blood and urine samples will be
taken at the beginning and at the end of each study period.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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