OptiGon - Optimising Laboratory Assays for Immune Responses to Gonococcus

Status Completed

Clinical Trial Summary

This is an observational study. Blood from otherwise healthy patients presenting with confirmed N.gonorrhoea infection, prior to treatment, will be collected to (i) allow the optimisation of assays assessing the immune response to gonococcus and (ii) assess whether N. gonorrhea specific responses can be detected on ELIspot +/- flow cytometry. The investigators plan to recruit up to 30 adults (men and women, aged 18-50 years) who have been diagnosed with confirmed N.gonorrhoea infection at the Sexual Health Clinic at the Oxford University Hospitals NHS Foundation Trust. The investigators will collect blood samples from consenting participants prior to them receiving curative antibiotic treatment.

Clinical Trial Description

On the day the patient attends the Sexual Health Clinic, they will be given the PIS to consider participation to the study following a confirmed positive result for N. gonorrhoea infection. Following written informed consent, a venous blood sample will be collected (up to 26 ml) on the same day. This will conclude that participant's involvement to the study. The blood sample will be transported to the laboratory at the Jenner Institute, University of Oxford for further analysis. ;

Study Design

Related Conditions & MeSH terms

Gonorrhea

Clinical Trial Details

NCT number	NCT05613725
Study type	Observational
Source	University of Oxford
Contact
Status	Completed
Phase
Start date	December 2, 2022
Completion date	April 30, 2024

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT01439503` - Safer Sex Program for Young African-American Men	Phase 2
Completed	`NCT00381992` - Risk Assessment of Long-Haul Truck Drivers	N/A
Completed	`NCT03294395` - New AntiBiotic Treatment Options for Uncomplicated Anogenital GOnorrhoea	Phase 3
Not yet recruiting	`NCT06428643` - A Seek, Test, and Treat Intervention to Reduce Chlamydia Trachomatis Disparities	N/A
Completed	`NCT03896776` - A Pragmatic Trial of Two Strategies for Implementing an Effective eHealth HIV Prevention Program (Keep It Up! 3.0)	N/A
Completed	`NCT03718806` - Study to Investigate Effect of Food and Safety of a New Formulation of Zoliflodacin	Phase 1
Completed	`NCT04010539` - A Study Evaluating Efficacy and Safety of Gepotidacin Compared With Ceftriaxone Plus Azithromycin in the Treatment of Uncomplicated Urogenital Gonorrhea	Phase 3
Completed	`NCT00262106` - Trial to Evaluate PRO 2000/5 Gels for the Prevention of Vaginally Acquired HIV Infection	Phase 3
Completed	`NCT00187902` - Evaluation of NAATs for Detection of C. Trachomatis and N. Gonorrhoeae From Pharynx, Rectum, Glans & Urethra of MSM	N/A
Completed	`NCT00207506` - Lay Health Advisors for Sexually Transmitted Disease Prevention	Phase 1/Phase 2
Completed	`NCT04553068` - Evaluation of EVO100 for Prevention of Urogenital Chlamydia Trachomatis and Neisseria Gonorrhoeae Infection	Phase 3
Active, not recruiting	`NCT03959527` - Zoliflodacin in Uncomplicated Gonorrhoea	Phase 3
Active, not recruiting	`NCT03980223` - Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users and HIV-infected Men Who Have Sex With Men	Phase 4
Completed	`NCT01465607` - Implementation of an Efficacious Intervention for High Risk Women in Mexico	N/A
Terminated	`NCT00120770` - Cellulose Sulfate (CS) Gel and HIV in Nigeria	Phase 3
Completed	`NCT02391233` - Multimedia WORTH With Black Drug-Involved Women on Probation	N/A
Recruiting	`NCT05766904` - Efficacy Trial on Meningococcal B Vaccine for Preventing Gonorrhea Infections	Phase 3
Completed	`NCT04297436` - Gonococcal Vaccine Study in Key Populations in Kenya	N/A
Completed	`NCT03098329` - Check it: A New Approach to Controlling Chlamydia Transmission in Young People	N/A
Completed	`NCT02122094` - Implementation of a Sexual Health Intervention for Young Men Who Have Sex With Men (MSM) in Two Vietnamese Cities	N/A