Gonorrhea Clinical Trial
Official title:
Antimicrobial Susceptibility Patterns of Neisseria Gonorrhea Isolates in an Era of Quinolone Resistance
To perform a laboratory sensitivity testing survey of antibiotic agents against Neisseria gonorrhea isolates from men with symptomatic urethritis seen at an STD clinic.
Until recently, the fluoroquinolones (ofloxacin, ciprofloxacin, levofloxacin) have been the
first line oral agents for the empiric treatment of gonorrhea. The prevalence of quinolone
resistant Neisseria gonorrheae (QRNG) has been rising since 2000. In 2006, the CDC updated
its guidelines to include recommendations against the use of quinolones for treatment of
Neisseria gonorrheae. Ceftriaxone (available only by intravenous or intramuscular route) was
named as the first line treatment for urogenital and pharyngeal disease. Availability, in
the United States, of the other two CDC recommended agents cefixime (oral) and spectinomycin
(IM) has been nonexistent.
At this time, there is little data on the in-vitro (laboratory test) susceptibility of
antibiotics against gonorrhea, particularly oral drugs. The purpose of this study is to
collect specimens of gonorrhea in a non-invasive swab manner from men with symptomatic
urethral discharges for laboratory sensitivity testing against a wide array of antibiotic
agents.
Specific Aims:
To perform a laboratory sensitivity testing survey of antibiotic agents against Neisseria
gonorrhea isolates from men with symptomatic urethritis seen at a Duval County STD clinic .
;
Observational Model: Case Control, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01439503 -
Safer Sex Program for Young African-American Men
|
Phase 2 | |
| Completed |
NCT00381992 -
Risk Assessment of Long-Haul Truck Drivers
|
N/A | |
| Completed |
NCT03294395 -
New AntiBiotic Treatment Options for Uncomplicated Anogenital GOnorrhoea
|
Phase 3 | |
| Not yet recruiting |
NCT06428643 -
A Seek, Test, and Treat Intervention to Reduce Chlamydia Trachomatis Disparities
|
N/A | |
| Completed |
NCT03896776 -
A Pragmatic Trial of Two Strategies for Implementing an Effective eHealth HIV Prevention Program (Keep It Up! 3.0)
|
N/A | |
| Completed |
NCT03718806 -
Study to Investigate Effect of Food and Safety of a New Formulation of Zoliflodacin
|
Phase 1 | |
| Completed |
NCT04010539 -
A Study Evaluating Efficacy and Safety of Gepotidacin Compared With Ceftriaxone Plus Azithromycin in the Treatment of Uncomplicated Urogenital Gonorrhea
|
Phase 3 | |
| Completed |
NCT00262106 -
Trial to Evaluate PRO 2000/5 Gels for the Prevention of Vaginally Acquired HIV Infection
|
Phase 3 | |
| Completed |
NCT00187902 -
Evaluation of NAATs for Detection of C. Trachomatis and N. Gonorrhoeae From Pharynx, Rectum, Glans & Urethra of MSM
|
N/A | |
| Completed |
NCT00207506 -
Lay Health Advisors for Sexually Transmitted Disease Prevention
|
Phase 1/Phase 2 | |
| Completed |
NCT04553068 -
Evaluation of EVO100 for Prevention of Urogenital Chlamydia Trachomatis and Neisseria Gonorrhoeae Infection
|
Phase 3 | |
| Active, not recruiting |
NCT03959527 -
Zoliflodacin in Uncomplicated Gonorrhoea
|
Phase 3 | |
| Active, not recruiting |
NCT03980223 -
Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users and HIV-infected Men Who Have Sex With Men
|
Phase 4 | |
| Completed |
NCT01465607 -
Implementation of an Efficacious Intervention for High Risk Women in Mexico
|
N/A | |
| Terminated |
NCT00120770 -
Cellulose Sulfate (CS) Gel and HIV in Nigeria
|
Phase 3 | |
| Completed |
NCT02391233 -
Multimedia WORTH With Black Drug-Involved Women on Probation
|
N/A | |
| Recruiting |
NCT05766904 -
Efficacy Trial on Meningococcal B Vaccine for Preventing Gonorrhea Infections
|
Phase 3 | |
| Completed |
NCT04297436 -
Gonococcal Vaccine Study in Key Populations in Kenya
|
N/A | |
| Completed |
NCT03098329 -
Check it: A New Approach to Controlling Chlamydia Transmission in Young People
|
N/A | |
| Completed |
NCT01836445 -
Keep It Up! 2.0: A Comparison of Two Online HIV Intervention Programs for Young Men Who Have Sex With Men
|
N/A |