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Clinical Trial Summary

This randomized trial aims to compare the euploid rate of blastocysts between PPOS and GnRH antagonist protocols in patients undergoing PGT-A. Infertile women who have medical indication for PGT-A will be recruited for study after explanation and counseling if they fulfill the inclusion criteria and do not have the exclusion criteria. Eligible women will be randomised into one of the two groups: Antagonist group: Women will receive antagonist once subcutaneously daily from day 6 of ovarian stimulation till the day of the ovulation trigger. PPOS group: Women will receive oral Duphaston 10mg bd from Day 3 till the day of ovulation trigger. The primary outcome is the euploidy rate of blastocysts.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04414748
Study type Interventional
Source ShangHai Ji Ai Genetics & IVF Institute
Contact HE LI, MD
Phone +8613817223099
Email lihe198900@163.com
Status Recruiting
Phase Phase 3
Start date June 10, 2020
Completion date December 1, 2025

See also
  Status Clinical Trial Phase
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Recruiting NCT03188471 - Preventive Application of GnRH Antagonist on Early OHSS Phase 4
Recruiting NCT02201914 - Clomiphene Citrate Plus Gonadotropins and GnRH Antagonist Versus Flexible GnRH Antagonist Protocol Versus Microdose GnRH Agonist Protocol in Poor Responders Undergoing IVF Phase 4
Completed NCT01286051 - Single Injection of Ganirelix in Gonadotropin Intrauterine Insemination (IUI) Cycles N/A
Not yet recruiting NCT05326087 - Comparison of the Euploid Rate of Blastocyst Between PPOS and GnRH Antagonist Protocol in Women With PCOS Undergoing PGT-A Phase 3