Influence of Beta-glucan Enriched Barley Flour in Bread on Glycemic

Status Completed

Clinical Trial Summary

Clinical Trial Description

Objective of the study is to investigate the influence of beta-glucan enriched barley flour as constituent of bread on glycaemic response (GR) in healthy human volunteers. Glycaemic response will be measured as the area under the curve (AUC) of blood glucose after consumption of barley bread(s), and compared with AUC for white bread. Measurements will be done in line with recommendations. In line with recommendations ten healthy human volunteers will be tested to obtain a sufficient statistical power. GR measurement will be based on available carbohydrates. Amount of bread will be standardised to contain 50 g of available carbohydrates. Subjects will consume bread sample with 250 mL of water, within 10-15 minutes. Blood sampling times will be at 0 min (baseline sample), followed by 15, 30, 45, 60, 90 and 120 min after starting to eat the test meal. Glucose levels will be measured in capillary blood. For reference and test meals, the investigators will do at least 2 AUC measurements per subject. AUC calculation will be based on incremental AUC, ignoring area under the baseline. Comparison will be done as the mean of the individual ratios.

The differences between the different products ingested will be analyzed with the statistical test of analysis of variance. In case of failure to find homogeneity in the variances the nonparametric ANOVA, the Kruskal-Wallis test, will be used. The results will be expressed as mean ± standard deviation for each with a significance level of 0.05 for all the statistical tests. ;

Study Design

Related Conditions & MeSH terms

Glycemic Index

Clinical Trial Details

NCT number	NCT02543164
Study type	Interventional
Source	Nutrition Institute, Slovenia
Contact
Status	Completed
Phase	N/A
Start date	February 2015
Completion date	September 2017

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Influence of Beta-glucan Enriched Barley Flour in Bread on Glycemic Response

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms