Effects of Nopal Fractions on Postprandial Glucose Regulation and Appetite Variables in Healthy Humans

Glucose Tolerance Clinical Trial

Official title:

Evaluation of Potentially Bioactive Foods With Regard to Their Effects on Cardiometabolic Test Markers and Cognitive Variables

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04439630
• Other study ID #: Protokoll 2018/8-b
• Status: Completed
• Phase: N/A
• Start date: July 1, 2020
• Est. completion date: August 1, 2020

Study information

• Verified date: October 2020
• Source: Lund University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Postprandial effects of Nopal fractions on glucose and appetite regulation will be investigated in healthy humans, in a randomised controlled crossover trial

Recruitment information / eligibility

• Status: Completed
• Enrollment: 24
• Est. completion date: August 1, 2020
• Est. primary completion date: August 1, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• Healthy

• non-smokers

• diet accordance with the Nordic Nutrition Recommendations

• BMI: 18.5-25 kg/m2

Exclusion Criteria:

• metabolic disorders

• food allergies

• no probiotics or other food /supplement which may interfere with the study

Related Conditions & MeSH terms

• Appetite Sensations
• Glucose Tolerance

Intervention

Dietary Supplement:
• Nopal fractions
Nopal flour were divided in two fractions and mixed in two different test breads
• Test product without the active components
Test product without the active components

Locations

Country	Name	City	State
Sweden	Food Technology, engineering and Nutrition, LTH, Lund University	Lund

Sponsors (1)

Lead Sponsor	Collaborator
Lund University

Country where clinical trial is conducted

Sweden, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	postprandial glucose tolerance	effects on postprandial glucose tolerance after intake of test products at breakfast. Measurements were performed at fasting (time = 0 min) and at 15, 30, 45, 60, 90, 120, 150 and 180 min.	0-180 min after start of the meal
Primary	postprandial insulin concentrations	effects on serum insulin concentrations after intake of test products at breakfast. Measurements were performed at fasting (time = 0 min) and at 15, 30, 45, 60, 90, 120, 150 and 180 min.	0-180 min
Secondary	subjective appetite variables	Subjective appetite variables (hunger, satiety, desire to eat) after intake of test products at breakfast, using a 100 mm Visual Analogue Scale (VAS) on a white paper. Except from a center mark in the center of the scale there was no other visible marks. Measurements were performed at fasting (time = 0 min) and at 15, 30, 45, 60, 90, 120, 150 and 180 min.	0-180 min