Glucose Tolerance Clinical Trial
Official title:
Effect of Acute Administration of Medicago Sativa on Glucose Tolerance, Insulin Secretion and Insulin Sensitivity in Normoglycemic, Overweight Adults
Previous preclinical investigations have found that Medicago sativa promotes the decrease of glucose concentrations. To evaluate the acute effect of Medicago sativa administration on glucose tolerance, insulin secretion, and insulin sensitivity in healthy individuals.
A randomized, double-blind, placebo-controlled, two-period, cross-over clinical trail will be
carrie out in 15 healthy, sedentary individuals of both genders, who meet the following
inclusion criteria: 25 to 40 years of age, normal fasting plasma glucose (≤ 5.5 mm/L), blood
pressure (<130/90 mmHg), body mass index of 25 to 29.9 kg/m2, no taking any medication known
to affect glucose tolerance, nondrinkers and nonsmokers. No pregnant, and lactation estate
for female participants. They will be select from the same neighborhood and socioeconomic
status.
After a fasting blood sample patients will be assigned at random-order through a
closed-envelope selection, to receive one of two possible sequences during which they
received either single oral doses of Medicago sativa or homologated placebo in 1,500 mg and
were crossover with a difference of at least 7 days washout interval. Thirty minutes after
each intervention patients underwent a 75-g oral glucose tolerant test (OGTT). Area under the
curve of glucose and insulin, phases of insulin secretion, and insulin sensitivity will be
calculate for each treatment period.
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