Exercise Type That Faster Reduces Postprandial Glycemia.

Glucose, High Blood Clinical Trial

— GLYEXER  

Official title:

Exercise Type That Faster Reduces Postprandial Glycemia.

Clinical Trial Details — Status: Enrolling by invitation

Administrative data

• NCT number: NCT04846751
• Other study ID #: PID2020-116159RB-I00
• Status: Enrolling by invitation
• Phase: N/A
• Start date: November 1, 2021
• Est. completion date: September 10, 2024

Study information

• Verified date: November 2022
• Source: University of Castilla-La Mancha
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

It is well established that a bout of 50 min of continuous moderate intensity exercise, improves insulin sensitivity up to 48 hours after the bout. However, it is less well known, what is the exercise type more efficient to buffer the elevations in blood glucose elicited by carbohydrate ingestion. The purpose of this study is to elucidate if intervalic exercise is superior to continous on improving postprandial glycemic control.

Description:

Carbohydrate oxidation, glucose and insulin blood concentrations, isotopically measured rate of appearance of endogenous and exogenous glucose will be measured in 4 ocassions. Participants will undergo in a cross-over randomized fashion the following trials: 1. Exercise pedalling during 50 min at 60% of their VO2max followed by an oral glucose tolerance test (OGTT). 2. Exercise pedalling during 50 min in a hot environment (33ºC) at 60% of their VO2max followed by an oral glucose tolerance test (OGTT). 3. Exercise pedalling during 50 min using intervalic bouts averaging 60% of VO2max followed by an oral glucose tolerance test (OGTT). 4. No exercise, followed by an oral glucose tolerance test (OGTT).

Recruitment information / eligibility

• Status: Enrolling by invitation
• Enrollment: 11
• Est. completion date: September 10, 2024
• Est. primary completion date: August 30, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• Participant must be capable and willing to provide consent, understand, instructions and protocols.
• Minimal fitness level to be able to complete 50 min of continous exercise at a moderate intensity.

Exclusion Criteria:

• Smokers
• Pregnancy
• Any non-controlled medical condition which could influence results or could be worsened by exercise

Related Conditions & MeSH terms

• Exercise-Induced Hyperinsulinism
• Glucose, High Blood
• Hyperinsulinism

Intervention

Behavioral:
• TYPE OF EXERCISE (OR REST)
continous exercise in normal temperature, continous exercise in hot environment, intervallic exercise in normal temperature.

Locations

Country	Name	City	State
Spain	University of Castilla-La Mancha (Exercise Physiology Lab)	Toledo

Sponsors (1)

Lead Sponsor	Collaborator
University of Castilla-La Mancha

Country where clinical trial is conducted

Spain, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Blood glucose concentration	Incremental area under the curve during the 120 min of the oral glucose tolerance test	16 weeks
Primary	Blood insulin concentration	Incremental area under the curve during the 120 min of the oral glucose tolerance test	16 weeks
Secondary	Carbohydrate oxidation	Measured using indirect calorimetry	16 weeks
Secondary	Turnover rate of endogenous and exogenous glucose	Measured using isotopic tracers.	16 weeks