Clinical Trial Details
— Status: Active, not recruiting
Administrative data
| NCT number |
NCT04582890 |
| Other study ID # |
Glomerulonephritis |
| Secondary ID |
|
| Status |
Active, not recruiting |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
April 30, 2021 |
| Est. completion date |
October 30, 2022 |
Study information
| Verified date |
July 2021 |
| Source |
Assiut University |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
US Time-Harmonic Elastography for the Early Detection of Childhood Glomerulonephritis
Description:
Glomerulonephritis (GN) comprises a group of renal diseases characterized by glomerular and
tubulointerstitial fibrosis secondary to glomerular inflammation and proliferation of the
basement membrane, mesangial cells, or capillary endothelium triggered by immunologic
mechanisms.(1) The glomerular filtration rate decreases with progression of chronic kidney
disease (CKD), ultimately resulting in end-stage renal failure. Glomerulonephritis is the
third most common cause of end-stage renal failure. Initial clinical signs of
glomerulonephritis are nonspecific and subtle. Occasionally, affected patients present with
hypertension, proteinuria, hematuria, raised serum creatinine level, weight gain, edema, or
nephrotic syndrome.(2) The underlying pathologic changes are partly irreversible, and a
prompt diagnosis with early initiation of treatment is of vital importance. The diagnosis is
based on clinical, laboratory, and conventional US findings, whereas renal biopsy is
considered the reference standard for a definitive diagnosis and fibrosis grading.(3,4)
Unfortunately, this invasive procedure is associated with the risk of serious bleeding
complications and therefore is not the method of choice for longitudinal monitoring.
Elastography, a Novel imaging modality that estimates tissue stiffness, especially for
superficial organs such as the breast and Thyroid. In recent years, ultrasound elastography
(UE) has been demonstrated in the liver and has been applied widely in the diagnosis and
evaluation of liver diseases, such as chronic hepatitis, alcoholic liver diseases, and non
alcoholic fatty liver diseases.(5,6) To date, renal allograft stiffness (elasticity) has been
evaluated by magnetic resonance elastography (MRE) and ultrasound elastography (UE). However,
UE application for native renal diseases has not been well up till now.(7) Conventional renal
ultrasonography may be appropriate to evaluate kidney size, as well as to assess the
echogenicity of the renal cortex, exclude obstruction, and determine the extent of fibrosis.
However, It has no significant role in diagnosis of GN. US time-harmonic elastography depicts
abnormal renal stiffness in glomerulonephritis, particularly among patients with early
disease and preserved renal function.(8,9,10)
