Glomerulonephritis, IGA Clinical Trial
Official title:
Study of the IgA Repertoire During IgA Deposition Nephropathy.
IgA plays a major role in mucosal and systemic immunity but retains mysterious and ambivalent
aspects. They can thus, depending on the situation, prove to be capable of triggering either
a protective inflammatory response or, on the contrary, anti-inflammatory and inducing
tolerance. Similarly, and for reasons that remain very poorly understood, they can be
involved in pathologies where the immune system is itself an aggressor of the body and
responsible for immunopathological lesions.
The investigator formulates the hypothesis that an inappropriate response of the mucosal
immune system to one or more antigens leads to a synthesis of IgA of bad affinity favoring a
deposit at the level of the mesangium. It seems important to verify this point by analyzing
the IgA repertory of patients with N-IgA and comparing it to that of a control population.
IgA plays a major role in mucosal and systemic immunity but retains mysterious and ambivalent
aspects. They can thus, depending on the situation, prove to be capable of triggering either
a protective inflammatory response or, on the contrary, anti-inflammatory and inducing
tolerance. Similarly, and for reasons that remain very poorly understood, they can be
involved in pathologies where the immune system is itself an aggressor of the body and
responsible for immunopathological lesions.
the investigator formulates the hypothesis that an inappropriate response of the mucosal
immune system to one or more antigens leads to a synthesis of IgA of bad affinity favoring a
deposit at the level of the mesangium. It seems important to verify this point by analyzing
the IgA repertory of patients with N-IgA and comparing it to that of a control population.
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