Globus Pharyngeus Clinical Trial
Official title:
Prevalence of Salivary Hypofunction in Patients With Globus Pharyngeus
It is well known that 'globus sensation in throat' is caused by the chronic irritation and
inflammation of oral, pharyngeal, or laryngeal mucosa, such as laryngopharyngeal reflux and
chronic postnasal drip.
Xerostomia and pharyngoxerosis due to salivary hypofunction also proved to induce the
mucosal change of the oral cavity and pharynx.
However, no previous studies have documented the prevalence of salivary hypofunction in
patients with globus pharyngeus.
Through this clinical investigation, we hypothesized that the salivary hypofunction might be
one of the leading cause of globus pharyngeus.
Subjects: patients with symptoms of globus pharyngeus
Globus symptom scoring: 0(mild) to 5(severe)
Subjective symptom analysis by "Standard Table for Xerostomia and Pharyngoxerosis"
Subjective physical finding analysis by "Standard Table for Xerostomia and Pharyngoxerosis"
Objective analysis of Salivary function by 99m-Tc Salivary scintigraphy
--> Define the prevalence of salivary hypofunction in patients with globus pharyngeus
(Primary end point)
Subsequent analysis (Secondary end point)
1. Group 1: Globus patients with objective salivary hypofunction
2. Group 2: Globus patients with normal salivary function
Intervention: Active management for xerostomia (Moisturizing, Gargling, Humidification,
Massage of salivary gland, Stimulant of salivary secretion, Artificial saliva)
Evaluation of the change of globus symptoms after active management of xerostomia between
the Group 1 and Group 2 (at 1 months, at 3 months after the initiation of intervention)
;
Observational Model: Case-Only, Time Perspective: Prospective
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