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Gliosarcoma of Brain clinical trials

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NCT ID: NCT06193174 Not yet recruiting - Clinical trials for Glioblastoma Multiforme of Brain

Re-Administration of C134 in Patients With Recurrent GBM (C134-HSV-1)

Start date: August 1, 2025
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine how safe and how well-tolerated the experimental study drug, C134 is when re-administered into the brain where the tumor is located.

NCT ID: NCT03657576 Recruiting - Clinical trials for Glioblastoma Multiforme of Brain

Trial of C134 in Patients With Recurrent GBM

C134-HSV-1
Start date: September 23, 2019
Phase: Phase 1
Study type: Interventional

The purpose of this project is to obtain safety information in small groups of individuals, scheduled to receive escalating doses of C134, a cancer killing virus (HSV-1) that has been genetically engineered to safely replicate and kill glioma tumor cells. Safety will be assessed at each dose level before proceeding to the next dose level. A special statistical technique called the Continual Reassessment Method (CRM) will be used to determine when higher doses of virus can be administered. Other objectives of the study include characterization of the activity of C134 after inoculation into the tumor and of the local and systemic immune responses to C134. Patients will also be followed with MRI scans for potential clinical response to C134. The clinical strategy takes advantage of the virus' ability to infect and kill tumor cells while making new virus within the tumors cells; a critical enhancement of this effect is accomplished by the induction of an anti-tumor immune response; both effects are produced by the IRS-1 gene that was placed into the virus by genetic engineering. An additional important component of the research are systematic assessments of the quality of life on treated patients.