Gliomas Clinical Trial
Official title:
The Application of ZOOMit-fMRI to Identify Motor Functional Cortex
This study was designed to collect a series of patients with gliomas which were involved in motor cortex to analyze difference accuracy of motor cortex localization between BOLD-fMRI and ZOOMit-fMRI.
Gliomas will lead motor dysfunction when they are involved in motor cortex. However, tumor
resection also have risk to lead postoperatively motor function deficits if destroy patients'
motor cortex when tumor removed. Hence, it is important for neurosurgeon to realize the
situation of patients' motor cortex locations in order to determine personal operative
protocol.
The blood oxygen level dependent fMRI (BOLD-fMRI) is a prevalent preoperative method to
localization motor cortex. It shows motor relevant cortex by the change of blood oxygen level
when patients cooperate to finish motor tasks. The advantage of BOLD-fMRI includes higher
time and spatial resolution, higher sensitivity, non-invasive. However, its accuracy of
localization has not been satisfactory because neurovascular uncoupling. The ZOOMit-fMRI is a
novel technic which is evolved from conventional BOLD-fMRI to localize motor functional
cortex.The advantage of ZOOMit-fMRI is smaller field of view (FOV) and higher spatial
resolution comparing with BOLD-fMRI. That helps to reduce other region of brain interference
and elevate accuracy of localizations.
In this study, the investigators plan to enroll 60 patients, whose gliomas are involved in
motor cortex, to acquire their BOLD-fMRI and ZOOMit-fMRI data in order to analyze their
difference in the accuracy of motor cortex localization.
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