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Use of Pulsed Low-dose Rate Re-irradiation for Recurrent Glioma (PULSAR) — PULSAR  

Glioma Clinical Trial

Official title:
A Phase-2 Trial to Investigate the Use of Pulsed Low-dose Rate Re-irradiation for Recurrent Glioma (PULSAR)

Clinical Trial Summary

Re-irradiation in gliomas is a therapeutic option at recurrence before of 2nd-line chemotherapy. The dose of re-irradiation with conventional fractionation is unfortunately limited by the risk of symptomatic radionecrosis that is significant for cumulative doses above 100 Gy. The use of unconventional low dose rate pulsed radiotherapy (pLDRT) can reduce the risk of radiotoxicity while taking advantage of the cellular hyper-radiosensitivity that occurs at low dose-rates. The present study therefore aims at evaluating whether the use of pLDRT in the re-irradiation of recurrences of gliomas allows maintaining a low risk of symptomatic radionecrosis even for cumulative doses greater than 100 Gy.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06055517
Study type Interventional
Source Centro di Riferimento Oncologico - Aviano
Contact Lorenzo Vinante, MD
Phone 0434659855
Email lorenzo.vinante@cro.it
Status Recruiting
Phase N/A
Start date May 26, 2023
Completion date May 26, 2028
View Details
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