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Low-dose Bevacizumab With HSRT vs BVZ Alone for GBM at First Recurrence

Glioma Clinical Trial

Official title:
A Randomized Phase II Trial of Concurrent Low-dose Bevacizumab and HSRT Versus Bevacizumab Alone for Glioblastoma at First Recurrence: HSCK-005

Clinical Trial Summary

This randomized phase II trial studies how well lose dose bevacizumab with Hypofractionated Stereotactic Radiotherapy (HSRT) works versus bevacizumab alone in treating patients with glioblastoma at first recurrence. The primary endpoint is 6-month progress-free survivaloverall survival after the treatment. Secondary endpoints included overall survival, objective response rate, cognitive function, quality of life and toxicity.

Clinical Trial Description

To establish an improvement in 6-month pfs in recurrent glioblastoma patients receiving low-dose bevacizumab and re-irradiation compared with patients receiving bevacizumab alone. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05611645
Study type Interventional
Source Huashan Hospital
Contact
Status Active, not recruiting
Phase Phase 2
Start date October 1, 2022
Completion date December 2025
View Details
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