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Surgical Window of Opportunity Study of Orally Administered BAY 2402234 in Recurrent Glioma

Glioma Clinical Trial

Official title:
An Open-Label Surgical Window of Opportunity Study Evaluating Pharmacodynamic Response of Orally Administered BAY 2402234 in Subjects With Recurrent Glioma, IDH Mutant, Grade 3 or 4

Clinical Trial Summary

This study aims to look at how BAY 2402234 responds in body in patients with recurrent glioma.

Clinical Trial Description

To characterize the biological activity of BAY 2402234 in recurrent glioma, IDH-mutant, Grade 3/4 using liquid chromatography-mass spectrometry (LC-MS). The tissue orotate:carbamoyl aspartate ratio will serve as the primary pharmacodynamic biomarker and will be characterized via LC-MS. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05061251
Study type Interventional
Source University of Texas Southwestern Medical Center
Contact
Status Withdrawn
Phase Early Phase 1
Start date December 1, 2021
Completion date December 1, 2023
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