Glioma Clinical Trial
Official title:
Organoids Derived From Induced-Pluripotent Stem Cells (iPS) From Patients
The objective of this study research proposal is to model human gliomagenesis using
3-Dimensional (3D) brain organoids derived from human induced pluripotent stem cells
(hiPSCs).
The working hypothesis is that 3D brain organoids can develop glioma-like structures and
recapitulate phenotypic traits of gliomas when generated from hiPSCs expressing genetic
mutants associated with glioma predisposition.
Methodology : To develop this pioneer study on the use of hiPSC-based brain organoids as a
strategy to model gliomagenesis and study the impact of genetic mutants, it will be collect
the peripheral blood mononuclear cell from 20 patients with high grade astrocytoma with or
without IDH mutation. iPS will be generated from these PBMC and will be genetically modified
according to different mutations. Then, it will be generate brain organoids according to
standard protocols. Brain organoids generated from all different cells will be collected at
different time points and analyzed for the presence of glioma-like structures and phenotypic
hallmarks of gliomas.
From the proposed experiments, it will be expect that brain organoids will develop
glioma-like features upon the presence of genetic mutations. Thus, it will be expect to
demonstrate that brain organoids can be used as a reliable strategy to test the impact of
genetic mutants, including the possible synergistic cooperation between different mutations
on early gliomagenic events.
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