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ONC201 in Adults With Recurrent H3 K27M-mutant Glioma

Glioma Clinical Trial

Official title:
A Phase II, Open-label Study of ONC201 in Adults With Recurrent High-grade Glioma

Clinical Trial Summary

The primary objective of this phase II trial is to determine the efficacy and safety of ONC201, an oral small molecule imipridone DRD2 antagonist, in adult subjects with recurrent high-grade glioma. This study will test the research hypothesis that histone H3 K27M mutation sensitizes to oral administration of ONC201 in gliomas.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03295396
Study type Interventional
Source Chimerix
Contact
Status Active, not recruiting
Phase Phase 2
Start date October 31, 2017
Completion date September 30, 2023
View Details
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