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A Study of High-Dose Chemoradiation Using Biologically-Based Target Volume Definition in Patients With Glioblastoma

Glioma Clinical Trial

Official title:
Phase II Study of High Dose Radiotherapy and Concurrent Temozolomide Using Biologically-Based Target Volume Definition in Patients With Newly Diagnosed Glioblastoma

Clinical Trial Summary

This is a study to determine the safety and effectiveness of high-dose radiation therapy (RT) with concurrent temozolomide in patients with newly diagnosed glioblastoma.

Clinical Trial Description

After analysis demonstrated the improved prognostic value of identifying both hypercellular tumor (TVHCV) based on high b-value diffusion-weighted magnetic resonance imaging (DW-MRI) and hyperperfused tumor (TVCBV) based on dynamic contrast-enhanced MRI (DCE-MRI), the study was amended and later-enrolled patients boosted to both TVHCV and TVCBV. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02805179
Study type Interventional
Source University of Michigan Rogel Cancer Center
Contact
Status Completed
Phase Phase 2
Start date September 22, 2016
Completion date November 18, 2020
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