Glioma Clinical Trial
Official title:
Non Invasive Measurements of Intracranial Pressure in Patients With Malignant Glioma
In patients at risk of increased intracranial pressure (ICP), ICP measurements require
invasive transducers, usually with insertion of a catheter into the cranium, or through a
spinal tap. These invasive modalities involve risks and pain and they can be done only in
specialized care units, with a high associated cost.
A novel method for detecting changes in ICP has developed recently. The auditory hair cells
emit sounds and electric signals in response to sound, which can be easily detected and
measured non-invasively with the help of a microphone probe placed in the external ear canal
or regular electrodes. Indeed, the cochlear aqueduct connects the cerebrospinal fluid (CSF)
spaces to the inner ear in such a way that ICP and inner-ear fluid pressure equalize within
seconds.
A symptom of intracranial pressure (ICP) was observed in glioma patient due to a combination
of causes: the inflammatory reaction around the tumor, the mass effect of the tumor,
secondary vascular changes, a change in the flow of CSF.
The evaluation of intracranial hypertension by increased ICP (invasive) is not used in the
monitoring of intracranial tumors. It is then detected by using routine clinical signs, in
combination with a standard imaging method (MRI), but still subjective.
The measurement of noninvasive ICP could allow earlier detection of relapse, and evaluate
whether the increase in ICP precedes tumor clinical worsening and / or imaging.
n/a
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