Identification of Genomic Changes in Families Having Multiple Members With Tumors

Glioma Clinical Trial

Official title:

Identification of Genomic Changes in Families Having Multiple Members With Tumors

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT02386241
• Other study ID #: 14BN108
• Status: Terminated
• Start date: March 2015
• Est. completion date: July 31, 2019

Study information

• Verified date: April 2024
• Source: St. Joseph's Hospital and Medical Center, Phoenix
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study will compare genomic alterations between the parents and the patients with high-grade glioma.

Description:

Genomic changes leading to the formation of brain tumors are slowly being discovered. Despite advances in genomic technology, much analysis is hindered by the lack of control samples that could better delineate genomic alterations leading to disease. The ideal genomic control would be the genetic material of the parents of afflicted individuals. The researchers propose to then compare the genomic material from parents of siblings, both of whom have a diagnosis of a high-grade glioma. Additionally, the researchers will then compare the genomic alterations between the parents and the patients. This analysis will provide an unprecedented insight into genomic level changes that take place between parents and patients that resulted in the formation of a high-grade glioma.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 4
• Est. completion date: July 31, 2019
• Est. primary completion date: July 31, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• 18 years or older.

• Family history of brain tumor in first degree relative

Exclusion Criteria:

• less than 18 years

Related Conditions & MeSH terms

• Glioma

Intervention

Other:
• saliva or blood sample collection
Single saliva or blood sample measuring 10mL for genomic analysis.

Locations

Country	Name	City	State
United States	Barrow Neurological Institute at St. Joseph's Hospital Medical Center	Phoenix	Arizona

Sponsors (2)

Lead Sponsor	Collaborator
St. Joseph's Hospital and Medical Center, Phoenix	Translational Genomics Research Institute

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Total genomic sequencing	Researchers will perform total genomic sequencing using next generation sequencing technology to identify common variants associated with familial brain tumors. Upon sequencing of the genomic material, the data analysis will be done using standard statistical methods. We will use bioinformatics tools (high throughput sequencing of genome) to identify genomic changes between parents and patients.	within 30 days of blood or saliva collection