Glioma Clinical Trial
Official title:
MicroRNAs as Disease Markers for Central Nervous System Tumors in Patients With Neurofibromatosis Type 1
MicroRNAs are small molecules which have recently been discovered in cells. They are known
to be responsible for the normal development of cells and when they are disrupted can
contribute to the development of cancer. Many previous studies have been done evaluating the
expression of microRNAs in normal tissues as well as in a wide variety of cancers.
Recently, microRNAs from tumor cells have been detected circulating in the blood of patients
with cancer. This presents a novel opportunity to assess the utility of microRNAs in the
blood as an early predictor of cancer as well as a marker of response to therapy. No
previous studies have been performed evaluating microRNAs in archived tumor tissue and blood
of patients with Neurofibromatosis type 1 (NF-1). The investigators propose a feasibility
study to evaluate the presence of microRNAs in archived tumor tissue and the blood of
patients with NF-1. If the investigators are able to identify circulating microRNAs in this
population of pediatric patients, they will build upon this data in proposing a future
study.
n/a
Observational Model: Case-Only, Time Perspective: Prospective
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