Glioma Clinical Trial
Official title:
Resection Control of Primary Brain Tumours Using a Low-Field Intraoperative MRI
Excision to the maximum possible extent marks the first step of glioma surgery. Depending on
tumour histology, adjuvant treatment consists of radio- and/or chemotherapy. Multi-centre
studies have shown that the presence of residual tumour according to MRI-criteria is a
prognostic factor in this incurable condition.
In order to improve the extent of resection, several methods, in particular intraoperative
imaging techniques, have become available to demonstrate already during surgery whether the
goal of surgery has been achieved. The intraoperative MRI devices currently available differ
in their magnetic field strengths and image resolution, but also in their amount of
interference with the surgical workflow.
Prospective, high-class evidence data to promote the use of intraoperative MRI in glioma
surgery are lacking. To assess whether the rate of radiologically complete tumour resections
can be improved by using intraoperative MRI-guidance, we designed this prospective,
randomized trial. We hypothesized that the extent of resection that can be achieved using an
intraoperative MRI is greater than that of conventional microsurgical tumor resection.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
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