Glioma Clinical Trial
Official title:
Impact of Multimodal Diagnostic Assessment of Cerebral Gliomas With F-18-fluoroethyl-L-tyrosine PET/CT, F-18-fluorocholine PET/CT and Magnetic Resonance Imaging and Spectroscopy
The aim of this study is to establish the diagnostic value of O-(2-[18F]-fluoroethyl)-L-tyrosine (FET) PET-CT, [18F]-fluorocholine (FCH) and magnetic resonance imaging (MRI) combined with magnetic resonance spectroscopy (MRS) in patients with suspected cerebral glioma using neuronavigated biopsies with histopathological analysis as reference.
The objectives of the study are:
- To demonstrate if the multimodal approach, combining the morphological aspect of the
MRI with the metabolic aspect of the tumor with magnetic resonance spectroscopy (MRS)
and O-(2-[18F]-fluoroethyl)-L-tyrosine (FET) or 18F]-fluorocholine (FCH) PET/CTthe FCH
allows to improve the location of a active metabolic tumor and its impact on the ideal
choice of sampling biopsy.
- To underline the differences and similarities between MRS and 18F]-fluorocholine PET /
CT in the assessment of metabolism of the choline. To establish the diagnosis value of
both methods, separately and in combination.
- To determine which examinations are useful and complementary for the diagnosis and the
management of gliomes.
FET combined with MRS may be a powerful, widely applicable new method to improve the
diagnosis of cerebral gliomas. The extent to which FCH and MRS provide similar information
is not known precisely and this study will establish their respective diagnostic value in
differentiating tumoral from non-tumoral tissue.
;
Observational Model: Cohort, Time Perspective: Prospective
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